ChemicalBook CAS DataBase List 3-NITRO-6-PYRIDINEMETHANOL

3-NITRO-6-PYRIDINEMETHANOL synthesis

8synthesis methods

Product Name:3-NITRO-6-PYRIDINEMETHANOL
CAS Number:36625-57-7
Molecular formula:C6H6N2O3
Molecular Weight:154.12

35969-75-6
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36625-57-7
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Yield:36625-57-7 60%

Reaction Conditions:

with methanol;sodium tetrahydroborate at 0; for 2 h;

Steps:

160.2 Step 2:

To a stirred solution of 5-nitropicolinaldehyde (350 g, 2.3mmol, 1.0 eq) in methanol (10 mL) was added NaBH4 (82 mg, 2.3 mmol, 1.0 eq) at 0 °C and resulting reaction mixture was stirred for 2 h. The reaction mixture was evaporated and residue dissolved in ethyl acetate (20 mL), washed with brine (30 mL), dried over sodium sulphate, evaporated to get (5-nitropyridin-2-yl)methanol (0.210 g, 60 %).

References:

WO2013/13815,2013,A1 Location in patent:Page/Page column 231

30563-98-5 Synthesis