3-oxo-3-(3-thienyl)propanenitrile synthesis
1synthesis methods
- Product Name:3-oxo-3-(3-thienyl)propanenitrile
- CAS Number:69879-30-7
- Molecular formula:C7H5NOS
- Molecular Weight:151.18
Yield:69879-30-7 53%
Reaction Conditions:
Stage #1: acetonitrilewith n-butyllithium in tetrahydrofuran;hexane at -78; for 1 h;
Stage #2: thiophene-3-carboxylic acid ethyl ester in tetrahydrofuran;hexane at -78; for 2 h;
References:
Xu, Kai;Liu, Hao;Hou, Yilin;Shen, Jiefeng;Liu, Delong;Zhang, Wanbin [Chemical Communications,2019,vol. 55,# 88,p. 13295 - 13298] Location in patent:supporting information