3-Picoline,2-(trimethylsilyl)-(8CI) synthesis
1synthesis methods
- Product Name:3-Picoline,2-(trimethylsilyl)-(8CI)
- CAS Number:13737-07-0
- Molecular formula:C9H15NSi
- Molecular Weight:165.31
Yield:13737-07-0 23%
Reaction Conditions:
Stage #1: 2-bromo-3-picolinewith n-butyllithium in diethyl ether;hexane at -78; for 1 h;Inert atmosphere;Schlenk technique;
Stage #2: chloro-trimethyl-silane in diethyl ether;hexane at -78 - 20; for 18 h;Inert atmosphere;Schlenk technique;
References:
Frogneux, Xavier;Von Wolff, Niklas;Thuéry, Pierre;Lefèvre, Guillaume;Cantat, Thibault [Chemistry - A European Journal,2016,vol. 22,# 9,p. 2930 - 2934] Location in patent:supporting information