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Chlorotrimethylsilane structure
Chemical Name:
CSI;TMCS;TMSCL;CT2950;tl1163;TL 1163;75-77-4;TSL 8031;SILANE M3;(CH3)3SiCl
Molecular Formula:
Formula Weight:
MOL File:

Chlorotrimethylsilane Properties

Melting point:
−40 °C(lit.)
Boiling point:
57 °C(lit.)
0.857 g/mL at 25 °C
vapor density 
3.7 (vs air)
vapor pressure 
100 mm Hg ( 25 °C)
refractive index 
n20/D 1.500
Flash point:
104 °F
storage temp. 
Store below +30°C.
Miscible with ether, benzene, diethylether and perchloroethylene.
Specific Gravity
0.8536 (27℃)
Clear colorless
explosive limit
Water Solubility 
Moisture Sensitive
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
Stable. Highly flammable - note low flash point. Reacts violently with water. Incompatible with water, moisture, strong oxidizing agents, strong acids, strong bases, aldehydes, alcohols, amines, esters, ketones.
CAS DataBase Reference
75-77-4(CAS DataBase Reference)
NIST Chemistry Reference
Silane, chlorotrimethyl-(75-77-4)
EPA Substance Registry System
Trimethylchlorosilane (75-77-4)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H303-H318-H290-H226-H302-H314-H335-H336-H351-H373-H225-H301+H331-H312-H331
Precautionary statements  P260h-P303+P361+P353-P501a-P261-P280-P305+P351+P338-P310-P210-P260-P370+P378-P403+P235-P301+P310-P233-P234-P240-P241+P242+P243-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501
Hazard Codes  T,F,C,Xn
Risk Statements  20/21-36/38-34-21-14-11-37-35-19-40-10-67-20/21/22-52
Safety Statements  26-36/37/39-45-16-36/37-7/9
RIDADR  UN 2924 3/PG 2
WGK Germany  2
RTECS  VV2710000
Autoignition Temperature 752 °F
Hazard Note  Highly Flammable/Corrosive/Moisture Sensitive
HazardClass  3
PackingGroup  II
HS Code  29310095
Toxicity LD50 orally in Rabbit: 4868 mg/kg LD50 dermal Rabbit 1530 mg/kg
NFPA 704
3 2

Chlorotrimethylsilane price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.18737 Chlorotrimethylsilane for synthesis 75-77-4 100 mL $37.28 2021-12-16 Buy
Sigma-Aldrich 384410 Chlorotrimethylsilane solution 1.0 M in THF 75-77-4 100ml $40.2 2021-12-16 Buy
Sigma-Aldrich 1.02333 Chlorotrimethylsilane for gas chromatography 75-77-4 100 mL $44.03 2021-12-16 Buy
Sigma-Aldrich 1.02333 Chlorotrimethylsilane for gas chromatography 75-77-4 250 mL $89.35 2021-12-16 Buy
Sigma-Aldrich 8.18737 Chlorotrimethylsilane for synthesis 75-77-4 500 mL $114.7 2021-12-16 Buy

Chlorotrimethylsilane Chemical Properties,Uses,Production

Chemical Properties

A clear, colorless, caustic and highly flammable liquid with a pungent odour. Readily hydrolyzed with liberation of hydrogen chloride; soluble in benzene, ether and perchloroethylene.

Chemical Properties

Trimethylchlorosilane is a colorless, fuming liquid. Irritating odor.

Physical properties

bp 57°C; d 0.856 g cm?3.


Related to the epoxide ring opening, TMSCl also mediates some cyclopropane ring opening reactions. For example, treatment of 1-aceto-2,2-dimethylcyclopropane with TMSCl and sodium chloride in acetonitrile at 55°C for 24 h generated 5-chloro-5-methyl-2-hexanone in 84% yield (eq 39).When sodium iodide was employed to replace sodium chloride, iodotrimethylsilane generated in situ, and the reaction completed under more facile conditions (rt and 12 h). Interestingly, the dominant product is 5-iodo-4,4-dimethyl-2-pentanone (eq 40), arising from iodide attacking at the less hindered secondary methylene carbon, instead of the quaternary dimethylmethylene carbon.


Trimethylsilyl chloride(TMCS) is the most extensively used derivatization reagent for gas chromatography.The reactions are generally performed under anhydrous conditions although reactions can be performed on samples obtained from water-containing samples.There are considerable opportunities for artifacts stemming from a variety of reasons including off-target reactions with aldehydes and ketones.The rate of reaction of TMCS with nucleophilic targets is comparatively slow compared to other alkylsilyl chlorides and requires the presence of a base catalyst such as pyridine.TMCS is included as a catalyst with other trialkylsilyl reagent such N,O-bis- (trimethylsilyl)trifluroacetamide (BSA) or N-methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA).The order of functional group reactivity is alcohols>phenols>carboxylic acids>amines>amides.


Chlorotrimethylsilane is a typical Silane Blocking Agent, which can protect or deprotect functional groups selectively. It is widely used in the syntheses of drugs. It have been used in the preparation of volatile derivatives of a wide range of compounds for GC analysis, and used for silylation and as a protection group in the process of various organic synthesis.


ChEBI: A silyl chloride consisting of a central silicon atom covalently bound to one chloro and three methyl groups. Chlorotrimethylsilane is a derivatisation agent used in gas chromatography/mass spectrometry applications.

General Description

A colorless fuming liquid with a pungent odor. Boiling point 135°F Flash point -18°F. Density 0.854 g / cm3. The vapor and liquid may cause burns. Vapors are heavier than air.

Reactivity Profile

Chlorotrimethylsilane reacts vigorously and exothermically with water to produce hydrogen chloride.

Health Hazard

Similar to other silanes. Toxicity is rated high for inhalation, ingestion and local irritation. May cause death or permanent injury after a very short exposure to small quantities.

Fire Hazard

Violent reaction with water. Toxic and irritating hydrogen chloride and phosgene may be formed in fires. Difficult to extinguish, re-ignition may occur. Flashback along vapor trail may occur. Containers may explode in fire. Vapor may explode if ignited in enclosed area. When heated to decomposition or on contact with acids or acid fumes, chloride fumes are emitted. Reacts with surface moisture, releasing hydrogen chloride, which will corrode common metals and form flammable hydrogen gas. Avoid contact with water; Chlorotrimethylsilane readily hydrolyzes, liberating hydrochloric acid. Hazardous polymerization may not occur.

Safety Profile

Poison by ingestion and skin contact. Moderately toxic by inhalation and intraperitoneal routes. A corrosive irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. A flammable liquid and very dangerous fire hazard when exposed to heat or flame. Violent reaction with water or hexafluoroisopropylideneamino lithium, A preparative hazard. To fight fire, use foam, alcohol foam, fog. When heated to decomposition it emits toxic fumes of Cl-. An intermediate in the production of silicones. See also CHLOROSILASES.

Potential Exposure

Trimethylchlorosilane is used as an intermediate to make silicone products, including lubricants


UN1298 Trimethylchlorosilane, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material.

Purification Methods

Likely impurities are other chlorinated methylsilanes and tetrachlorosilane (b 57.6o), some of which can form azeotropes. To avoid the latter, very efficient fractional distillation is required. It has been fractionated through a 12 plate glass helices-packed column with only the heart-cut material being used. It has also been fractionated through a 90cm, 19mm diameter Stedman column (p 11). Purify it by redistilling from CaH2 before use. [Sauer et al. J Am Chem Soc 70, 4254 1948, Sauer & Hadsell J Am Chem Soc 70 4258 1948, Langer et al. J Org Chem 23 50 1958, Beilstein 4 IV 4007.] FLAMMABLE and CORROSIVE.


Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Chlorosilanes react vigorously with bases and both organic and inorganic acids generating toxic and/or flammable gases. Chlorosilanes react with water, moist air, or steam to produce heat and toxic, corrosive fumes of hydrogen chloride. They may also produce flammable gaseous hydrogen. Attacks metals in the presence of moisture. Vigorous reaction with aluminum powder.

Waste Disposal

Do not discharge into drains or sewers. Use a licensed disposal contractor to an approved landfill. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office for guidance on acceptable disposal practices. The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Chlorotrimethylsilane Preparation Products And Raw materials

Raw materials

Preparation Products

Chlorotrimethylsilane Suppliers

Global( 466)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 15427 58
Hangzhou Bayee Chemical Co., Ltd.
0086-571-85775919 China 105 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 China 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 China 1807 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 26782 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418697 China 3000 55
+86-571-8723 8903
+86-571-87063838 CHINA 997 58
Tianjin Zhongxin Chemtech Co., Ltd.
+8618622897568 +86-022-66880623
022-66880086 China 543 58
career henan chemical co
+86-0371-55982848 China 29954 58
13867897135 CHINA 925 58

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View Lastest Price from Chlorotrimethylsilane manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Chlorotrimethylsilane
US $15.00 / KG 1KG 99% 50 ton Hebei Crovell Biotech Co Ltd
2021-11-08 Chlorotrimethylsilane
US $10.00 / KG 1KG 99% 20 tons Wuhan wingroup Pharmaceutical Co., Ltd
2021-07-13 Trimethyl chlorosilane
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Chlorotrimethylsilane Spectrum

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