3-(TETRAHYDRO-FURAN-2-YL)-PROPIONIC ACID synthesis
- Product Name:3-(TETRAHYDRO-FURAN-2-YL)-PROPIONIC ACID
- CAS Number:935-12-6
- Molecular formula:C7H12O3
- Molecular Weight:144.17
539-47-9
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935-12-6
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Yield:935-12-6 93%
Reaction Conditions:
with hydrogen;palladium on activated charcoal in methanol at 60; under 3102.97 Torr; for 12 h;
Steps:
67.67A
Example 67A; 3 -(tetrahydrofuran-2-yl)propanoic acid; (E)-3-(Furan-2-yl)acrylic acid (10 g, 72.4 mmol) was treated with Pd/C (Ig) in MeOH (100 mL). The mixture was heated at 60 0C at 60 psi under H2 for 12 hrs. After filtering off the catalyst, the filtrate was concentrated to afford 9.8 g (93 %) of the title compound. 1H NMR (500 MHz, CDCl3) δ ppm 1.42 - 1.56 (m, 1 H) 1.77 - 1.96 (m, 4 H) 1.93 - 2.07 (m, 1 H) 2.41 - 2.56 (m, 2 H) 3.71 - 3.79 (m, 1 H) 3.82 - 3.94 (m, 2 H); MS (DCI/NH4+) m/z 145 (M + H)+.
References:
WO2008/130953,2008,A2 Location in patent:Page/Page column 79
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404003-12-9
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821-09-0
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64-69-7
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