4-Benzyloxy-2-(2carbomethoxy)thiophenylnitrobenzene synthesis
- Product Name:4-Benzyloxy-2-(2carbomethoxy)thiophenylnitrobenzene
- CAS Number:329217-03-0
- Molecular formula:C21H17NO5S
- Molecular Weight:395.43
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Yield:-
Reaction Conditions:
Stage #1: Thiosalicylic acidwith sodium hydride in N,N-dimethyl acetamide;
Stage #2: 4-(benzyloxy)-2-bromo-1-nitrobenzene in N,N-dimethyl acetamide at 80; for 1 h;
Stage #3: methyl iodide in N,N-dimethyl acetamide at 20; for 45 h;Further stages.;
References:
Warawa;Migler;Ohnmacht;Needles;Gatos;McLaren;Nelson;Kirkland [Journal of Medicinal Chemistry,2001,vol. 44,# 3,p. 372 - 389]