Propanoic acid, 3,3,3-trifluoro-2-hydroxy-2-Methyl-, Methyl ester synthesis
3synthesis methods
- Product Name:Propanoic acid, 3,3,3-trifluoro-2-hydroxy-2-Methyl-, Methyl ester
- CAS Number:337-16-6
- Molecular formula:C5H7F3O3
- Molecular Weight:172.1
Yield:337-16-6 78%
Reaction Conditions:
with sulfuric acid in methanol; for 20 h;Reflux;Inert atmosphere;
References:
Rueeger, Heinrich;Lueoend, Rainer;Machauer, Rainer;Veenstra, Siem J.;Holzer, Philipp;Hurth, Konstanze;Voegtle, Markus;Frederiksen, Mathias;Rondeau, Jean-Michel;Tintelnot-Blomley, Marina;Jacobson, Laura H.;Staufenbiel, Matthias;Laue, Grit;Neumann, Ulf [Journal of Medicinal Chemistry,2021,vol. 64,# 8,p. 4677 - 4696] Location in patent:supporting information
