4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE synthesis
- Product Name:4-BROMO-1-[(4-METHYLPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDINE
- CAS Number:348640-07-3
- Molecular formula:C14H11BrN2O2S
- Molecular Weight:351.22
98-59-9
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$9.00/5g
348640-06-2
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$6.00/250mg
348640-07-3
103 suppliers
$47.00/1g
Yield:348640-07-3 100%
Reaction Conditions:
with sodium hydride in tetrahydrofuran;mineral oil;
Steps:
In an ice bath, 4-bromo-7-azaindole (25.5 mmol, 5 g) and p-toluenesulfonyl chloride (38.25 mmol, 7.27 g) were added to a reaction flask, dissolved in 100 mL of anhydrous tetrahydrofuran, 60%NaH (30 mmol, 1.2 g) was slowly added, and the mixture was reacted at room temperature for 6 hours. The reaction was stopped, 50 mL of water was slowly added, the organic solvent was dried by rotary evaporation, extracted with dichloromethane, dried over anhydrous Na2SO4, and separated by column chromatography to afford intermediate a2 (9.0 g, quantitative yield), LC-MS: [M + H] +: 350.
References:
EP3967694,2022,A1 Location in patent:Paragraph 0148
55052-24-9
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$80.00/5G
348640-07-3
103 suppliers
$47.00/1g
271-63-6
569 suppliers
$9.00/5g
348640-07-3
103 suppliers
$47.00/1g