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ChemicalBook CAS DataBase List 3-Furancarboxylic acid, 4,5-dihydro-2-methyl-4-oxo-, ethyl ester

3-Furancarboxylic acid, 4,5-dihydro-2-methyl-4-oxo-, ethyl ester synthesis

1synthesis methods
-

Yield:3511-34-0 44%

Reaction Conditions:

Stage #1: ethyl acetoacetatewith magnesium ethylate in ethanol;benzene at 23; for 1.5 h;Inert atmosphere;
Stage #2: chloroacetyl chloride in ethanol;acetonitrile;benzene at 0 - 23; for 3 h;Inert atmosphere;

References:

Zhurakovskyi, Oleksandr;Türkmen, Yunus E.;L?ffler, Lorenz E.;Moorthie, Vijayalakshmi A.;Chen, C. Chun;Shaw, Michael A.;Crimmin, Mark R.;Ferrara, Marco;Ahmad, Mushtaq;Ostovar, Mehrnoosh;Matlock, Johnathan V.;Aggarwal, Varinder K. [Angewandte Chemie - International Edition,2018,vol. 57,# 5,p. 1346 - 1350][Angew. Chem.,2018,vol. 130,p. 1360 - 1364,5] Location in patent:supporting information

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