(S)-ethyl 4-oxo-1-((R)-1-phenylethyl)piperidine-2-carboxylate synthesis
- Product Name:(S)-ethyl 4-oxo-1-((R)-1-phenylethyl)piperidine-2-carboxylate
- CAS Number:357154-19-9
- Molecular formula:C16H21NO3
- Molecular Weight:275.34
924-44-7
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2627-86-3
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3886-69-9
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![Ethyl (2R)-4-oxo-1-[(1R)-1-phenylethyl]-2-piperidinecarboxylate](/CAS/20210305/GIF/357154-18-8.gif)
357154-18-8
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357154-19-9
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Yield:-
Reaction Conditions:
Stage #1: glyoxylic acid ethyl ester;(S)-1-phenyl-ethylaminewith 3 A molecular sieve in dichloromethane;toluene at 0; for 0.75 h;
Stage #2: (R)-1-phenyl-ethyl-aminewith boron trifluoride diethyl etherate;trifluoroacetic acid in dichloromethane;toluene at -65 - -30;
References:
Lau, Jesper F;Kruse Hansen, Thomas;Paul Kilburn, John;Frydenvang, Karla;Holsworth, Daniel D;Ge, Yu;Uyeda, Roy T;Judge, Luke M;Sune Andersen, Henrik [Tetrahedron,2002,vol. 58,# 36,p. 7339 - 7344]
![Acetic acid, 2-[oxido[(1R)-1-phenylethyl]imino]-, ethyl ester](/CAS/20210305/GIF/357154-20-2.gif)
357154-20-2
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357154-19-9
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