2-AMINO-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID(2-HYDROXY-ETHYL)-AMIDE synthesis

Yield:362003-35-8 31%

Reaction Conditions:

in ethanol;Reflux;

Steps:

4.1.12. 2-Amino-4-methyl-N-substituted-thiazole-5-carboxamides(13a-c)

General procedure: To a solution of the thiazole 1 (0.93 g, 5 mmol) in ethanol (15 mL), the appropriate amine was added and the mixture was heated under reflux for 10-12 h. After being cooled to room temperature, the separated solid was filtered, washed with cold ethanol, dried and recrystallized. Physicochemical and analytical data are recorded in Table 3. IR (cm^-1): 3540-2775 (NH, OH), 1685-1645 (C=O).

References:

Rostom, Sherif A.F.;Faidallah, Hassan M.;Radwan, Mohammed F.;Badr, Mona H. [European Journal of Medicinal Chemistry,2014,vol. 76,p. 170 - 181]