3-(4-METHOXYPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXYLIC ACID synthesis
- Product Name:3-(4-METHOXYPHENYL)-4-OXO-3,4-DIHYDRO-1-PHTHALAZINECARBOXYLIC ACID
- CAS Number:36710-94-8
- Molecular formula:C16H12N2O4
- Molecular Weight:296.28
Yield:36710-94-8 87%
Reaction Conditions:
in ethanol;water at 20; for 15 h;
Steps:
General procedure for preparation of 4-oxo-3-substituted phenyl-3,4-dihydrophthalazine-1-carboxylic acid (23a-h)
General procedure: To a solution of 22 (13 g, 0.067 mol) in water (100 mL), an appropriate phenyl hydrazine (0.067 mol) in ethanol (200 mL) was added. After stirring at room temperature for 15 h, the resultant precipitate was filtered, washed with dichloromethane and dried under vacuum to afford the title compounds 23a-h.
References:
Liu, Zijian;Wang, Rui;Guo, Ruiming;Hu, Jinxing;Li, Ruijuan;Zhao, Yanfang;Gong, Ping [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 14,p. 3642 - 3653]
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