phthalonic acid synthesis
- Product Name:phthalonic acid
- CAS Number:528-46-1
- Molecular formula:C9H6O5
- Molecular Weight:194.14
91-20-3
519 suppliers
$13.19/250mg
528-46-1
27 suppliers
$305.00/250mg
Yield: 45.3%
Reaction Conditions:
with potassium permanganate;sodium hydroxide in water at 100;
Steps:
5.1.11 Preparation of 2-carboxyethl formyl benzoic acid (11)
Potassium permanganate (132.5g, 0.84mol) in H2O (937.0mL) was added drop-wise to the vigorously stirred liquated solution of naphthalene (20.0g, 0.16mol) in sodium hydroxide solution (312.0mL, 0.5mol). After completion of reaction as indicated by TLC, ethanol (30.0mL) was added and stirred for another 15min. The mixture was then cooled and filtered, and the filtrate was acidified by concentrated hydrochloric acid (93.8mL) and evaporated to dryness to give the compound 11 as a white solid (14.2g, 45.3%). MS (ESI) m/z: 195.1 [M+H]+
References:
Zhao, Sijia;Zhang, Yu;Zhou, Hongyang;Xi, Shuancheng;Zou, Bin;Bao, Guanglong;Wang, Limei;Wang, Jiao;Zeng, Tianfang;Gong, Ping;Zhai, Xin [European Journal of Medicinal Chemistry,2016,vol. 120,p. 37 - 50]
201230-82-2
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88-65-3
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528-46-1
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88-99-3
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65-85-0
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$10.00/25 g
88-65-3
349 suppliers
$5.00/5g
528-46-1
27 suppliers
$305.00/250mg
88-99-3
471 suppliers
$15.00/50 g
65-85-0
1397 suppliers
$10.00/25 g
88-67-5
561 suppliers
$5.00/5g
528-46-1
27 suppliers
$305.00/250mg
88-99-3
471 suppliers
$15.00/50 g
65-85-0
1397 suppliers
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201230-82-2
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118-91-2
671 suppliers
$8.50/5g
528-46-1
27 suppliers
$305.00/250mg
88-99-3
471 suppliers
$15.00/50 g
65-85-0
1397 suppliers
$10.00/25 g