2,4(1H,3H)-Pyrimidinedione, 6-methyl-, 2-hydrazone (9CI) synthesis
- Product Name:2,4(1H,3H)-Pyrimidinedione, 6-methyl-, 2-hydrazone (9CI)
- CAS Number:37893-08-6
- Molecular formula:C5H8N4O
- Molecular Weight:140.14
6328-58-1
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Yield:37893-08-6 85%
Reaction Conditions:
with hydrazine hydrate in ethanol at 80; for 5.5 h;
Steps:
1.1.2 Step 2: Synthesis of 2-hydrazinyl-6-methyl-3,4-dihydropyrimidin-4-one (Intermediate 1) [00131] (EV-AN7477-001) (Intermediate 1)
[00132] To a stirred solution of 6-methyl-2-(methylsulfanyl)-3,4-dihydropyrimidin-4-one (11.9 g, 76.18 mmol) in EtOH (30 mL) was added hydrazine hydrate (15.75 mL, 0.32 mol) and stirred at 80 °C for 5.5 h. The reaction mixture was allowed to cool to r.t. and the resulting precipitate was collected and dried by vacuum filtration, washing with water (3 mL) to afford the title compound (9.20 g, 85%) as an off white powder. [00133] Method A: LC-MS m/z = 140.90 [M + H]+; RT = 0.18 min.
References:
WO2017/59191,2017,A1 Location in patent:Paragraph 00130-00133
21418-88-2
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53736-37-1
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56-04-2
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$5.00/100mg
37893-08-6
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56-04-2
376 suppliers
$5.00/100mg
37893-08-6
40 suppliers
inquiry