Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List (E)-Ethyl 3-(4-(benzyloxy)-3-Methoxyphenyl)acrylate
38157-08-3

(E)-Ethyl 3-(4-(benzyloxy)-3-Methoxyphenyl)acrylate synthesis

8synthesis methods
4-BENZYLOXY-3-METHOXYBENZALDEHYDE

2426-87-1

Ethyl (triphenylphosphoranylidene)acetate

1099-45-2

(E)-Ethyl 3-(4-(benzyloxy)-3-Methoxyphenyl)acrylate

38157-08-3

GENERAL METHOD: Ethoxycarbonylmethylenetriphenylphosphine (1.55 g, 4.46 mmol) was added to a stirred solution of 4-benzyloxy-3-methoxybenzaldehyde (0.73 g, 3.72 mmol) in benzene (10 mL). The reaction mixture was then refluxed for 4 hours. Upon completion of the reaction, the solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/petroleum ether, 1:19) to afford the target product ethyl (E)-3-(4-(benzyloxy)-3-methoxyphenyl)acrylate (0.89 g, 90% yield) as a white solid.

-

Yield:38157-08-3 99%

Reaction Conditions:

in dichloromethane at 20; for 6 h;Wittig Olefination;

References:

Lalwani, Komal G.;Sudalai, Arumugam [European Journal of Organic Chemistry,2015,vol. 2015,# 33,p. 7344 - 7351]