Methyl-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxylate synthesis
- Product Name:Methyl-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxylate
- CAS Number:38934-69-9
- Molecular formula:C9H13N3O6
- Molecular Weight:259.22
4928-88-5
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13035-61-5
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38934-69-9
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Yield:38934-69-9 246.92 g
Reaction Conditions:
with trifluorormethanesulfonic acid at 55; for 1 h;Microwave irradiation;
Steps:
1 Synthesis of methyl 1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylate
In a 2000 ml three-necked flask equipped with a thermometer and mechanical stirring, add 318.03 g (1 mol) of tetraacetyl ribose.127.10g (1mol) of triazole methyl ester, 20.06g of trifluoromethanesulfonic acid, placed in a microwave reactor, set power 400W, heated to 55 ° C, heat preservation reaction for 60 min,Cool to room temperature, add 1000 ml of methanol, dissolve by heating, and pour out.After cooling, a large amount of white solid precipitated, filtered, washed and dried.Methyl 1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxylate 346.92 g.
References:
CN109134566,2019,A Location in patent:Paragraph 0047; 0050; 0051
58-63-9
657 suppliers
$5.00/25g
38934-69-9
40 suppliers
$63.00/1mg
13035-61-5
590 suppliers
$5.00/25g
38934-69-9
40 suppliers
$63.00/1mg