ChemicalBook CAS DataBase List 2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]corey lactone

2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]corey lactone synthesis

9synthesis methods

Product Name:2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]corey lactone
CAS Number:39968-95-1
Molecular formula:C14H26O4Si
Molecular Weight:286.44

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2-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]corey lactone

39968-95-1
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Yield:39968-95-1 192 g

Reaction Conditions:

with lithium bromide monohydrate in acetone at 70 - 80; for 15 h;Temperature;

Steps:

2

34 g of the solid obtained in the previous step was dissolved with 3 liters of acetone, 1 kg of LiBr.H2O and 1.5 kg of polyethylene glycol 4000 were added,70-80 ° C reaction,Reflux for 15 hours. The material was filtered and rinsed with 800 ml of X3 ethyl acetate,The filtrate was concentrated,Adding 900 ml of n-hexane,20 degrees stirring for 2 hours,(3aR, 4S, 5R, 6aS) -5-tert-butyldimethylsiloxy-4-tetramethylolhexahydro-2H-cyclopenta [b] furan-2-one as a white solid filter,drying,Get 192 grams,Two-step yield of 77%

References:

CN103570757,2017,B Location in patent:Paragraph 0023; 0024; 0026; 0029

32233-40-2 Synthesis