3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE synthesis
- Product Name:3H-BENZO[4,5]THIENO[3,2-D]PYRIMIDIN-4-ONE
- CAS Number:36822-08-9
- Molecular formula:C10H6N2OS
- Molecular Weight:202.23
![3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER](/CAS/GIF/34761-09-6.gif)
34761-09-6
65 suppliers
$20.00/250mg
3473-63-0
514 suppliers
$5.00/25g
36822-08-9
34 suppliers
$41.00/100mg
Yield:36822-08-9 94.1%
Reaction Conditions:
in 2-methoxy-ethanol at 150;Inert atmosphere;
Steps:
2.2 Step 2: Synthesis of benzo[4,5]thiophene[3,2-d]pyrimidin-4(3H)-one
Dissolve 3-aminobenzothiophene-2-carboxylic acid ethyl ester (5g, 23mmol), and formamidine acetate (7.2g, 69mmol) in 23mL of ethylene glycol methyl ether,The reaction system was evacuated to change nitrogen, heated to 150°C and refluxed overnight,After TLC detects that the reaction is complete, the system is cooled to room temperature, the product is precipitated, filtered, and the product is washed with ethanol until the filtrate is colorless.The solid was collected and dried to obtain an off-white granular solid benzo[4,5]thiophene[3,2-d]pyrimidin-4(3H)-one (4.38g, 94.1%).
References:
CN111440216,2020,A Location in patent:Paragraph 0141; 0145-0147
34761-09-6
65 suppliers
$20.00/250mg
60100-09-6
0 suppliers
inquiry
36822-08-9
34 suppliers
$41.00/100mg
394-47-8
482 suppliers
$5.00/5g
36822-08-9
34 suppliers
$41.00/100mg
![METHYL 3-AMINOBENZO[B]THIOPHENE-2-CARBOXYLATE](/CAS/GIF/35212-85-2.gif)
35212-85-2
89 suppliers
$12.00/1g
36822-08-9
34 suppliers
$41.00/100mg
7716-66-7
278 suppliers
$32.00/5g
36822-08-9
34 suppliers
$41.00/100mg