(3S)-3-AMINO-3-(2,3-DIFLUOROPHENYL)PROPANOIC ACID synthesis

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: methylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.25 h / 20 °C / Inert atmosphere
1.2: 15 h / Inert atmosphere; Reflux
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 °C / Inert atmosphere
2.3: -78 - 20 °C / Saturated solution
3.1: Pd(OH)2/C (6% w/w); hydrogen / methanol / 24 h / 20 °C / 3800.26 Torr
4.1: hydrogenchloride; water / 6 h / Reflux
4.2: Dowex 50WX₈-100

References:

Davies, Stephen G.;Fletcher, Ai M.;Lv, Linlu;Roberts, Paul M.;Thomson, James E. [Tetrahedron Asymmetry,2012,vol. 23,# 11-12,p. 910 - 925]