4-(1-chloroethyl)-1,2-difluorobenzene synthesis
- Product Name:4-(1-chloroethyl)-1,2-difluorobenzene
- CAS Number:221031-54-5
- Molecular formula:C8H7ClF2
- Molecular Weight:176.59
321318-21-2
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Yield:221031-54-5 89%
Reaction Conditions:
with thionyl chloride in dichloromethane at 20; for 12 h;
Steps:
2.18
1-(3,4-difluorophenyl)ethanol (900 mg, 5.69 mmol) was dissolved in CH2Cl2 (15 ml), slowly added with SOCl2 (1354 mg, 11.38 mmol), and stirred at room temperature for 12 hours. After the reaction was completed, the resultant mixture obtained through concentration was purified by column chromatography (EA/n-Hex = 1:5) so as to provide 4-(1-chloroethyl)-1,2-difluorobenzene (1 g, 5.66 mmol, 89 %).[230] 1H NMR (400 MHz, CDCl3) δ 7.31-7.25 (m, 1H), 7.19-7.10 (m, 2H), 5.07-5.02 (m, 1H), 1.85-1.83 (m, 3H).
References:
WO2012/128582,2012,A2 Location in patent:Page/Page column 39
369-33-5
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