4-(1-Methyl-1H-pyrazol-3-yl)benzoic acid synthesis
- Product Name:4-(1-Methyl-1H-pyrazol-3-yl)benzoic acid
- CAS Number:915707-39-0
- Molecular formula:C11H10N2O2
- Molecular Weight:202.21
14047-29-1
476 suppliers
$10.00/5G
151049-87-5
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$21.00/1g
915707-39-0
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$680.00/250mg
Yield:915707-39-0 61%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;sodium carbonate in 1,2-dimethoxyethane at 100; for 4 h;Inert atmosphere;
Steps:
3-(1-methyl-1H-pyrazol-4-yl)benzoic acid (CP_01)
General procedure: To a solution of 4-bromo-1-methyl-1H-pyrazole(161 mg, 1 mmol) in DME (15 mL) and 2N Na2CO3 (5 mL) wasadded 3-carboxyphenylboronic acid (237 mg, 1.5 mmol) and [1,1’-bis(diphenylphosphino)ferrocene]-dichloropalladium(II)(73 mg, 0.1 mmol). The reaction mixture was heated to 100 °C for 4 h under a nitrogenatmosphere. The mixture was cooled, filtered and concentrated to dryness. Theresidue was purified by silica gel chromatography (DCM/MeOH = 20:1) to yieldthe title compound (CP_01, 140 mg, 69%)as a colorless oil.
References:
Bi, Xiaoyang;Chen, Yu;Sun, Zhongya;Lu, Wenchao;Xu, Pan;Lu, Tian;Ding, Hong;Zhang, Naixia;Jiang, Hualiang;Chen, Kaixian;Zhou, Bing;Luo, Cheng [Bioorganic and Medicinal Chemistry Letters,2020,vol. 30,# 22,art. no. 127480] Location in patent:supporting information
179057-11-5
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$400.00/1g
915707-39-0
21 suppliers
$680.00/250mg