4-(1H-BENZIMIDAZOL-2-YLTHIO)ANILINE synthesis
- Product Name:4-(1H-BENZIMIDAZOL-2-YLTHIO)ANILINE
- CAS Number:956-13-8
- Molecular formula:C13H11N3S
- Molecular Weight:241.31
Yield:956-13-8 85%
Reaction Conditions:
with triethylamine in ethanol; for 5.66667 h;Reflux;
Steps:
2.4 General Procedure for the C-S CouplingReaction Catalyzed by CuMTPOF
General procedure: The catalytic activity of CuMTPOF was tested for one ofthe important reactions i.e., C-S coupling. The C-S couplingreaction is generally carried out using homogeneous catalysts. However, their applications were confined dueto the separation and recycling of the steeply-priced Cucatalystsfrom the reaction mixture. Here MTPOF basedheterogeneous Cu is utilized as a catalyst for performingthe C-S coupling reaction. In this reaction a mixture of substitutedaryl halide (0.5 mmol), 2-mercaptobenzimidazole(0.5 mmol), CuMTPOF (0.05 g) and Et3N(3 eq,) in ethanol(10 mL), was refluxed for 2 h. After completion of thereaction, the catalyst was separated by centrifugation andwashed several times with ethanol, afterward filtrate wasadded to ice-cold water. The solid obtained was filtered anddried under vacuum. The crude products were purified bycolumn chromatography and characterized by NMR spectroscopy(see Supplementary information).
References:
Dani, Shilpa H.;Pratap, Umesh R. [Catalysis Letters,2022]
![1H-Benzimidazole, 2-[(4-nitrophenyl)thio]-](/CAS/20210305/GIF/39544-81-5.gif)
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