4-(2-bromoethyl)-1,2-dichlorobenzene synthesis
- Product Name:4-(2-bromoethyl)-1,2-dichlorobenzene
- CAS Number:39232-02-5
- Molecular formula:C8H7BrCl2
- Molecular Weight:253.95
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Yield:39232-02-5 33%
Reaction Conditions:
with carbon tetrabromide;triphenylphosphine in dichloromethane at 20;
Steps:
4.1 4-(2-Bromoethyl)-1,2-dichlorobenzene
2-(3,4-Dichlorophenyl)ethan-1-ol (500 mg, 2.62 mmol), 27 triphenylphosphine (1.03 g, 3.93 mmol) and 28 tetrabromomethane (1.30 g, 3.93 mmol) were dissolved in 29 dichloromethane (20 mL). The reaction mixture was stirred for overnight in the room temperature. The reaction mixture was concentrated under reduced pressure. The residue was purified on an ISCO chromatography (0-10% ethyl acetate/hexane) to give the 20 product as colorless oil (219 mg, 33%); 1H NMR (300 MHz) (CDCl3) δ 7.39 (d, J=8 Hz, 1H), 7.31 (d, J=2 Hz, 1H), 7.06 (dd, J=8 Hz, J=2 Hz, 1H), 3.54 (t, J=7 Hz, 2H), 3.12 (t, J=7 Hz, 2H).
References:
US2019/31624,2019,A1 Location in patent:Paragraph 0408-0409
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1449 suppliers
$14.00/1KG
35364-79-5
133 suppliers
$14.00/1g
39232-02-5
17 suppliers
inquiry