4-(2-FLUORO-4-NITROPHENOXY)-7-AZAINDOLE synthesis
2synthesis methods
- Product Name:4-(2-FLUORO-4-NITROPHENOXY)-7-AZAINDOLE
- CAS Number:888720-59-0
- Molecular formula:C13H8FN3O3
- Molecular Weight:273.22
Yield:888720-59-0 70.6%
Reaction Conditions:
in chlorobenzene at 190; for 30 h;
Steps:
General procedure: A mixture of 15a or 15b (0.03 mol) and 2-fluoro-4-nitrophenolor 4-nitrophenol 16a-b (45 mmol) in chlorobenzene (50 mL) wasreacted at 190 C for 30 h. Then the mixture was then poured into abeaker containing petroleum ether (100 mL). The precipitate wascollected by filtration, and dried to afford the desired product 17ad.
References:
Zhang, Jianqing;Dai, Jintian;Lan, Xin;Zhao, Ying;Yang, Feiyi;Zhang, Han;Tang, Sheng;Liang, Guang;Wang, Xu;Tang, Qidong [European Journal of Medicinal Chemistry,2022,vol. 233,art. no. 114215]
