4-[(2-FLUOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE synthesis
- Product Name:4-[(2-FLUOROBENZYL)OXY]-3-METHOXYBENZALDEHYDE
- CAS Number:423156-68-7
- Molecular formula:C15H13FO3
- Molecular Weight:260.26
446-48-0
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$6.00/10g
121-33-5
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423156-68-7
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$60.00/100mg
Yield:423156-68-7 100%
Reaction Conditions:
with potassium carbonate;potassium iodide in DMF (N,N-dimethyl-formamide);
Steps:
6 4-(2-Fluoro-benzyloxy)-3-methoxy-benzaldehyde
Example 6 4-(2-Fluoro-benzyloxy)-3-methoxy-benzaldehyde 0.5M solution of 1-bromomethyl-2-fluoro-benzene (1.5 mg, 8 mmol) in DMF was added dropwise to a suspension of 3-methoxy-4-hydroxy-benzaldehyde (1.1 g, 7.3 mmol), K2CO3 (1.51 g, 11 mmol) and KI (120 mg, 7.3 mmol) in DMF (100 ml). The reaction mixture was treated as described in Example 4. The residue was purified on silica gel, obtaining 1.89 g (quantitative yield) of the title compound, yield 100%.
References:
EP1535908,2005,A1 Location in patent:Page/Page column 12
345-35-7
316 suppliers
$13.43/1gm:
121-33-5
1146 suppliers
$9.00/1g
423156-68-7
28 suppliers
$60.00/100mg