4,4'-(1,3-PHENYLENEDIISOPROPYLIDENE)BISPHENOL synthesis

Yield:-

Steps:

C.1 Comparative Example 1
Comparative Example 1 75.2 g (0.8 mol) of phenol and 22.5 g of sulfonic acid type ion exchange resin (Amberlist 15) were placed in a four necked one liter capacity flask. A mixed solution of 77.6 g (0.4 mol) of 1,3-di(2-hydroxy-2-propyl)benzene and 150.4 g (1.6 mol) of phenol was added dropwise from a 300 mL capacity dropping funnel to the phenol in the flask at a temperature of 45° C. for four hours. After the addition, a post-reaction was effected at the same temperature for five hours. Throughout the reaction, however, the reaction mixture was remained solution and no crystallization took place. After the reaction, the resulting reaction mixture was subjected to quantitative analysis of 1,3-di(2-p-hydroxyphenyl-2-propyl)benzene therein by means of HPLC to show that 65.0 g of the desired product were formed in a reaction yield of 47.0 mol % based on 1,3-di(2-hydroxy-2-propyl)benzene used.

References:

Honshu Chemical Industry Co. Ltd. US6326522, 2001, B1

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