4,4’-(1,4-phenylenebis(ethyne-2,1-diyl))dianiline synthesis
- Product Name:4,4’-(1,4-phenylenebis(ethyne-2,1-diyl))dianiline
- CAS Number:246141-52-6
- Molecular formula:C22H16N2
- Molecular Weight:308.38
Yield:246141-52-6 96%
Reaction Conditions:
with C16H20Cl2N2O2Pd;potassium hydroxide in water;acetonitrile at 60; for 12 h;Sonogashira Cross-Coupling;
Steps:
31. General procedure for Sonogashira coupling reaction
General procedure: In a 10 mL round bottom flask, the palladium complex (0.010 mmol) was dissolved in acetonitrile (2 mL). Aryl halide (1.0 mmol), alkyne (1.2 mmol), KOH (2.00 mmol) and distilled water (2 mL) were added. The mixture was stirred at room temperature (or 60° C) for the required time. After reaction completion, the product was extracted with ethyl acetate (3x5 mL). The combined organic layers were dried with anhydrous sodium sulfate. The product was analyzed with GC and GC-MS. The product was purified using column chromatography with hexane-ethyl acetate as eluent. The characterization data were in entire agreement with the previously reported literature.32-39
References:
Ibrahim, Mansur B.;Ali, Bassam El;Malik, Imran;Fettouhi, Mohammed [Tetrahedron Letters,2016,vol. 57,# 5,p. 554 - 558]
935-14-8
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