4-(4-Chloro-2-thienyl)-2-thiazolamine synthesis
- Product Name:4-(4-Chloro-2-thienyl)-2-thiazolamine
- CAS Number:570407-10-2
- Molecular formula:C7H5ClN2S2
- Molecular Weight:216.71
Bromine was added to an ether solution of 4-chloro-2-acetylthiophene under ice cooling, and the mixture was stirred at room temperature for 2 hours to obtain a brominated compound. Thiourea was added to an EtOH solution of the brominated compound at room temperature, and the mixture was stirred overnight at 80°C to obtain 2-amino-4-(4-chlorothiophen-2-yl)thiazole.
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Yield:-
Reaction Conditions:
Stage #1:1-(4-chlorothiophen-2-yl)ethan-1-one with bromine in diethyl ether at 0 - 20; for 2 h;
Stage #2:thiourea in ethanol at 20 - 80;
Steps:
13
Reference Example 13; Bromine was added to an ether solution of 4-chloro-2-acetylthiophene under ice cooling, and the mixture was stirred at room temperature for 2 hours to obtain a brominated compound. Thiourea was added to an EtOH solution of the brominated compound at room temperature, and the mixture was stirred overnight at 80°C to obtain 2-amino-4-(4-chlorothiophen-2-yl)thiazole.
References:
Astellas Pharma Inc. EP1647553, 2006, A1 Location in patent:Page/Page column 18
