4-(4-Chlorophenyl)tetrahydro-2H-pyran synthesis
- Product Name:4-(4-Chlorophenyl)tetrahydro-2H-pyran
- CAS Number:1187926-98-2
- Molecular formula:C11H13ClO
- Molecular Weight:196.67
103502-34-7
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1187926-98-2
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Yield:1187926-98-2 99%
Reaction Conditions:
with 3-methyl-1-(butyl-4-sulfonyl)imidazolium trifluoromethanesulfonate at 120; for 24 h;Sealed tube;
Steps:
15 Example 15. Ionic liquid [SO3H-BMIm][OTf] catalyzed the dehydration of 3-p-chlorophenyl-1,5-pentanediol to prepare 3-p-chlorophenyl-tetrahydropyran
Place 0.1 mol of ionic liquid and 0.2 mol of 3-p-chlorophenyl-1,5-pentanediol in a 20 ml temperature-resistant glass reaction tube and seal it; move it to an oil bath at 120 °C, stir and heat for 24 hours for dehydration ring The reaction was terminated by immersing the reaction tube in ice water, and then placed at room temperature for a period of time; then, the phase composition of 3-p-chlorophenyl-tetrahydropyran was analyzed by gas chromatography, and the phase composition of ionic liquid was analyzed by nuclear magnetic resonance. According to the analysis results, the conversion rate of 3-p-chlorophenyl-1,5-pentanediol was 100%, the selectivity of 3-p-chlorophenyl-tetrahydropyran was 100%, and the yield was >99%.
References:
CN114437000,2022,A Location in patent:Paragraph 0086-0087
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29943-42-8
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