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Tetrahydro-4H-pyran-4-one

Application Description
Tetrahydro-4H-pyran-4-one
Tetrahydro-4H-pyran-4-one structure
CAS No.
29943-42-8
Chemical Name:
Tetrahydro-4H-pyran-4-one
Synonyms
4-THP;EOS-60523;Oxan-4-one;1KG,10KG,25KG;TETRAHYDRO-GAMM;4-Oxacyclohexanone;TetrahydroHpyranone;Tetrahydro-4-pyrone;4-Oxotetrahydopyran;Tetrahydropyran-4-on
CBNumber:
CB3703050
Molecular Formula:
C5H8O2
Formula Weight:
100.12
MOL File:
29943-42-8.mol

Tetrahydro-4H-pyran-4-one Properties

Boiling point:
166-166.5 °C (lit.)
Density 
1.084 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.452(lit.)
Flash point:
134 °F
storage temp. 
Inert atmosphere,Room Temperature
form 
Liquid
color 
Clear colorless to pale yellow
Water Solubility 
MISCIBLE
BRN 
106463
InChIKey
JMJRYTGVHCAYCT-UHFFFAOYSA-N
CAS DataBase Reference
29943-42-8(CAS DataBase Reference)
NIST Chemistry Reference
4H-Pyran-4-one, tetrahydro-(29943-42-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02
Signal word  Warning
Hazard statements  H227-H226
Precautionary statements  P210e-P280a-P370+P378a-P501a-P210-P233-P240-P241+P242+P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
Hazard Codes  Xi,F
Risk Statements  10-36/37/38
Safety Statements  24/25-36-26
RIDADR  UN 1224 3/PG 3
WGK Germany  3
10
Hazard Note  Keep Cold/Flammable/Irritant
HazardClass  3.2
PackingGroup  III
HS Code  29329995
NFPA 704
2
1 0

Tetrahydro-4H-pyran-4-one price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 198242 Tetrahydro-4H-pyran-4-one 99% 29943-42-8 1g $35.8 2021-03-22 Buy
Sigma-Aldrich 198242 Tetrahydro-4H-pyran-4-one 99% 29943-42-8 5g $139 2021-03-22 Buy
TCI Chemical T1806 Tetrahydro-4H-pyran-4-one >95.0%(GC) 29943-42-8 1g $32 2021-03-22 Buy
TCI Chemical T1806 Tetrahydro-4H-pyran-4-one >95.0%(GC) 29943-42-8 5g $94 2021-03-22 Buy
Alfa Aesar A19010 Tetrahydro-4H-pyran-4-one 98% 29943-42-8 5g $130 2021-03-22 Buy

Tetrahydro-4H-pyran-4-one Chemical Properties,Uses,Production

Application

Tetrahydro-4-pyrone is used in organic synthesis as a building block for more complex chemical structures because it participates in a variety of cycloaddition reactions. Tetrahydro-4H-pyran-4-one is employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid and it undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. Tetrahydro-4H-pyran-4-one is also employed in wittig reactions for the synthesis of penicillins and in a ring of vitamin D3. Additionally, tetrahydro-4-pyrone is used as solvents in some reactions.

Description

Tetrahydro-4H-pyran-4-one is used in organic synthesis as building block for more complex chemical structures because it participate in a variety of cycloaddition reactions. Tetrahydro-4H-pyran-4-one is employed in the preparation of 4-methoxytetrahydropyran-4-yl protecting group, synthesis of symmetric tetra substituted methanes. 
The methyl enol ether is a useful protecting agent for alcohols, e.g. in nucleotide synthesis, with the advantage over 3,4-Dihydro-2H-pyran. Tetrahydro-4H-pyran-4-one is also employed in a study of the enantioselective alpha-aminoxylation of ketones with nitrosobenzene and L-proline in an ionic liquid. It undergoes condensation reactions in the preparation of dipeptides and spiroimidazolones. Tetrahydro-4H-pyran-4-one is also employed in wittig reactions for the synthesis of Penicillins and in a ring of vitamin D3.

Chemical Properties

colorless to light yellow liquid

Uses

Tetrahydro-4-pyrone is used in organic synthesis as building block for more complex chemical structures because it participate in a variety of cycloaddition reactions.

Purification Methods

Purify the pyrone by repeated distillation, preferably in a vacuum. [Baker J Chem Soc 296 1944, IR: Olsen & Bredoch Chem Ber 91 1589 1958.] The oxime has m 87-88o and b 110-111o/13mm [Cornubert et al. Bull Soc Chim Fr 36 1950]. The 4-nitrophenylhydrazone forms orange-brown needles from EtOH, m 186o [Cawley & Plant J Chem Soc 1214 1938]. [Beilstein 17 I 131, 17 II 287, 17 III/IV 4171, 17/9 V 21.]

Tetrahydro-4H-pyran-4-one Preparation Products And Raw materials

Raw materials

Preparation Products


Tetrahydro-4H-pyran-4-one Suppliers

Global( 353)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Nantong Xiaochang Pharmaceutical Trading Co., Ltd.
17602153959 0513-81283365-
sales8@btcpharm.com CHINA 286 58
Zjartschem
+86-571-8723 8903 jocelynpan@zjarts.com
+86-571-87063838 jocelynpan@zjarts.com CHINA 997 58
Suzhou Ryan Pharmachem Technology Co.,Ltd.
0512-68780025-8002
0512-68780025-8004 yybi@ryanchem.com;sales@ryanchem.com CHINA 188 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20010 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55

Related articles


View Lastest Price from Tetrahydro-4H-pyran-4-one manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-12 Tetrahydro-4H-pyran-4-one
29943-42-8
US $40.00 / KG 1KG 99 10 tons Shijiazhuang tongyang Import and Export Co., LTD
2020-09-22 Tetrahydro-4H-pyran-4-one
29943-42-8
US $50.00 / KG 1KG 99.9% 20tons Hebei Runbin Biotechnology Co. LTD
2020-04-28 Tetrahydro-4H-pyran-4-one
29943-42-8
US $0.01-1.00 / KG 1KG 99% 50 tons Shaanxi Dideu Medichem Co. Ltd

Tetrahydro-4H-pyran-4-one Spectrum


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