4-(4-FLUOROPHENYL)-2(3H)-THIAZOLONE synthesis
- Product Name:4-(4-FLUOROPHENYL)-2(3H)-THIAZOLONE
- CAS Number:834885-06-2
- Molecular formula:C9H6FNOS
- Molecular Weight:195.21
43045-16-5
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Yield:-
Reaction Conditions:
with sulfuric acid in ethanol;water;acetic acid at 100; for 1 h;
Steps:
30.a
1.085 g (5 mmol) of 2-bromo-1-(4-fluoro-phenyl)-ethanone and 405 mg (5 mmol) of sodium thiocyanate in 40 ml of ethanol were heated under reflux for 30 min. Then 20 ml of ethanol were distilled off, water was added, the precipitate was filtered off, 10 ml of acetic acid, 0.5 ml of water and 0.2 ml of concentrated sulfuric acid were added, and the mixture was stirred at 100 °C for 1 h. After dilution with water, the precipitated product was filtered off, washed with water and dried. Yield: 782 mg. MS: m/e = 195 (M+H)+
References:
EP1939181,2008,A1 Location in patent:Page/Page column 50
766-98-3
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