4-(4-fluorophenyl)tetrahydropyran-2,6-dione synthesis

6synthesis methods

459-57-4 Synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: piperidine / 72 h / 20 °C
1.2: aq. KOH / 3 h / 80 - 95 °C
2.1: AcCl / 3 h

References:

Fryszkowska, Anna;Komar, Marta;Koszelewski, Dominik;Ostaszewski, Ryszard [Tetrahedron Asymmetry,2005,vol. 16,# 14,p. 2475 - 2485]

3449-63-6 Synthesis

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