4,4'-[hexane-1,6-diylbis(oxy)]bisbenzonitrile synthesis
- Product Name:4,4'-[hexane-1,6-diylbis(oxy)]bisbenzonitrile
- CAS Number:94291-61-9
- Molecular formula:C20H20N2O2
- Molecular Weight:320.39
Yield:94291-61-9 94.52%
Reaction Conditions:
Stage #1: 4-hydroxybenzonitrilewith natrium in ethanol; for 1 h;Reflux;
Stage #2: 1 ,6-dibromohexane in ethanol; for 3 h;Reagent/catalyst;Solvent;
Steps:
ii Example ii: Sodium is added as a strong base to the reaction system:
Weigh 20.36gNa was added to a 250ml three-necked flask containing 25ml of ethanol until Na was completely dissolved.To this, 200 ml of an ethanol solution containing 51.0 g of p-cyanophenol was added dropwise to control the feeding rate so that the reaction temperature was maintained at 25 to 30,After the addition was completed, the mixture was slowly heated to reflux. After 1 hour of reaction, 40.4 g of 1,6-dibromohexane was added dropwise to the reaction system to control the feeding rate. After completion of the addition, the reaction was carried out for 3 hours.After the reaction was completed, the temperature was lowered to below 10 , stirred for 2 hours, filtered and the filter cake was dried to give 55.4g of white powder. Yield: 94.52%.
References:
CN105884652,2016,A Location in patent:Paragraph 0027; 0028; 0029
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