4-(5-FORMYL-2-FURYL)BENZOIC ACID synthesis
- Product Name:4-(5-FORMYL-2-FURYL)BENZOIC ACID
- CAS Number:39245-15-3
- Molecular formula:C12H8O4
- Molecular Weight:216.19
53355-29-6
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39245-15-3
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Yield:39245-15-3 96%
Reaction Conditions:
with methanol;water;lithium hydroxideReflux;Inert atmosphere;
Steps:
4.1.3 General procedure for the synthesis of compounds 8a-d
General procedure: LiOH (10mmol) was added to a solution of compounds 7a-e (1mmol) in CH3OH (10mL) and H2O (5mL). The reaction mixture was refluxed till ester disappeared in TLC (～1h), acidified with HCl 2N till pH 4-5 and extracted with AcOEt (3×25mL). The combined organic layers were washed with a NaHCO3 saturated solution (2×20mL) and brine (2×20mL). The desired products 8a-e were obtained as brown-red solid after evaporation of the solvent.
References:
Gentili, Valentina;Turrin, Giulia;Marchetti, Paolo;Rizzo, Sabrina;Schiuma, Giovanna;Beltrami, Silvia;Cristofori, Virginia;Illuminati, Davide;Compagnin, Greta;Trapella, Claudio;Rizzo, Roberta;Bortolotti, Daria;Fantinati, Anna [Bioorganic Chemistry,2022,vol. 119,art. no. 105518]
1899-24-7
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14047-29-1
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39245-15-3
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98-01-1
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150-13-0
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39245-15-3
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27329-70-0
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619-58-9
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39245-15-3
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![Benzoic acid, 4-[5-(dimethoxymethyl)-2-furanyl]-](/CAS/20210305/GIF/263158-18-5.gif)
263158-18-5
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39245-15-3
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$45.00/50mg