
4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine synthesis
- Product Name:4-(5-isopropoxy-2-Methyl-4-nitrophenyl)pyridine
- CAS Number:1032903-62-0
- Molecular formula:C15H16N2O3
- Molecular Weight:272.3

1032903-50-6
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$6.00/100mg

1692-15-5
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1032903-62-0
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Yield: 81%
Reaction Conditions:
with dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane;tris-(dibenzylideneacetone)dipalladium(0);C31H44ClN7O3S in 1,4-dioxane;water at 120; for 0.666667 h;Microwave irradiation;Inert atmosphere;
Steps:
54.1 Step 1: 4-(5-isopropoxy-2-methyl-4-nitrophenyl) pyridine
Step 1:
4-(5-isopropoxy-2-methyl-4-nitrophenyl) pyridine
1-chloro-5-isopropoxy-2-methyl-4-nitrobenzene (0.85g, 3.7mmol), 4-pyridine boronic acid (0.5g, 4.1mmol), tris (dibenzylideneacetone) dipalladium (0.34g, 0.37mmol), 2-dicyclohexyl phosphino-2 ', 6'-dimethoxy-biphenyl (S-phos) (0.38g, 0.93mmol), potassium phosphate trihydrate (2g, 7.51mmol), 1,4-dioxane (6mL) and water (3mL) were added to a 20mL microwave tube.
The reaction mixture was heated up to 120°C by microwave under the protection of nitrogen and stirred for 40 minutes.
After completion of the reaction, the reaction solution was added with ethyl acetate, washed with saturated brine, dried and concentrated.
The thus obtained crude product was separated and purified by column chromatography (silica gel column, eluent: ethyl acetate/petroleum ether, gradient:
0∼50% ethyl acetate) to obtain the title compound (yellow solid, 0.81g, 81%).
(MS: [M+1] 273.1)
References:
Beijing Pearl Biotechnology Limited Liability Company;DONG, Jiaqiang;ZHONG, Boyu;YUAN, Hongbin;SHI, Quan;CHU, Shaosong;ZHANG, Deyi;ZHANG, Ruihao EP3150592, 2017, A1 Location in patent:Paragraph 0211; 0212; 0213

1032903-50-6
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$6.00/100mg

19524-06-2
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$6.00/5g

1032903-62-0
123 suppliers
$13.00/250mg

1032903-50-6
149 suppliers
$6.00/100mg

19524-06-2
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$6.00/5g

73183-34-3
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1032903-62-0
123 suppliers
$13.00/250mg

112108-73-3
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$8.00/5g

1032903-62-0
123 suppliers
$13.00/250mg

452-73-3
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$6.00/25g

1032903-62-0
123 suppliers
$13.00/250mg