Pyridine-4-boronic acid
- CAS No.
- 1692-15-5
- Chemical Name:
- Pyridine-4-boronic acid
- Synonyms
- PYRIDIN-4-YLBORONIC ACID;4-PYRIDINEBORONIC ACID;4-PYRIDYLBORONIC ACID;4-PYRIDINYLBORONIC ACID;Pyridin-4-ylboronic acid, 97%, May contain varying aMounts of anhydride;AKOS BRN-0273;4-Boronopyridine;BUTTPARK 43\57-08;4-Pyridineboronic;TIMTEC-BB SBB004280
- CBNumber:
- CB7220144
- Molecular Formula:
- C5H6BNO2
- Molecular Weight:
- 122.92
- MDL Number:
- MFCD01074545
- MOL File:
- 1692-15-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >300 °C (lit.) |
|---|---|
| Boiling point | 308.8±34.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Aqueous Acid (Slightly), Water (Slightly) |
| form | Solid |
| pka | 7.59±0.10(Predicted) |
| color | White to Off-White |
| BRN | 471944 |
| InChI | InChI=1S/C5H6BNO2/c8-6(9)5-1-3-7-4-2-5/h1-4,8-9H |
| InChIKey | QLULGIRFKAWHOJ-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(B(O)O)=C1 |
| CAS DataBase Reference | 1692-15-5(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn,Xi,C,F | |||||||||
| Risk Statements | 36/37/38-22-34-11 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26-45-16 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, KEEP COLD | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Pyridine-4-boronic acid price More Price(95)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 634492 | 4-Pyridinylboronic acid 90% | 1692-15-5 | 1g | $47.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 634492 | 4-Pyridinylboronic acid 90% | 1692-15-5 | 5g | $123 | 2026-04-30 | Buy |
| TCI Chemical | P1594 | 4-Pyridylboronic Acid (contains varying amounts of Anhydride) | 1692-15-5 | 1g | $20 | 2026-04-30 | Buy |
| TCI Chemical | P1594 | 4-Pyridylboronic Acid (contains varying amounts of Anhydride) | 1692-15-5 | 5g | $64 | 2026-04-30 | Buy |
| TRC | TRC-P991355-25G | 4-Pyridineboronic Acid | 1692-15-5 | 25g | $202 | 2026-06-03 | Buy |
Pyridine-4-boronic acid Chemical Properties, Uses, Production
Uses
Pyridine-4-boronic acid can be used as a candidate for Suzuki-Miyaura coupling reaction. Especially, as a N-containing building blocks, pyridine-4-boronic acid was employed to construct some heterocyclic compounds with superior biological activities.
Description
Pyridine-4-boronic acid is a kind of boronic acid derivative. It is useful building blocks in crystal engineering. It can also be used as a catalyst to act as a dehydrative condensation agent to synthesize amides using carboxylic acid and amines as raw materials. Its derivative, polystyrene-bound 4-pyridineboronic acid, is a useful catalyst for amidation reaction and esterification of alpha-hydrocarboxylic acids.
Chemical Properties
light orange granular powder
Uses
Boronic acid derivatives and their binding affinities with diols.
Uses
Reagent used for
- Palladium-catalyzed Suzuki-Miyaura coupling reactions
- Ligand-free palladium-catalyzed Suzuki coupling reaction under microwave irradation
Reagent used in Preparation of
- HIV-1 protease inhibitors
- Potential cancer threapeutics, such as PDK1 and protein kinase CK2 inhibitors
Uses
suzuki reaction
Synthesis
1120-87-2
121-43-7
7732-18-5
1692-15-5
Under argon protection, 4-bromopyridine (1.5 g, 10 mmol) was placed in a 200 mL Schlenk flask and 40 mL of anhydrous deoxytetrahydrofuran was added. After cooling the reaction mixture to -78 °C, 5 mL (2.2 M, 11 mmol) of n-butyllithium solution was slowly added dropwise and the reaction was maintained at this temperature for 1 hour. Subsequently, 4 mL of trimethyl borate was added and the reaction continued at -78 °C for 1 hour. Upon completion of the reaction, the mixture was slowly warmed to room temperature and stirred overnight. The reaction was quenched with 2 mol/L hydrochloric acid solution and purified by recrystallization from hexane to give pyridine-4-boronic acid hydrochloride (0.8 g, 65% yield).
References
http://www.wako-chem.co.jp/english/labchem/product/Org/pyridineboronic/
José J. CamposGaxiola et al. "Pyridineboronic Acids as Useful Building Blocks in Combination with Perchloroplatinate(II) and -(IV) Salts: 1D, 2D, and 3D Hydrogen-Bonded Networks Containing X-H•••Cl2Pt− (X = C, N+), B(OH)2•••Cl2Pt−, and B(OH)2•••(HO)2B Synthons." Crystal Growth & Design 10.7(2010).
Kara, H., A. G. Orpen, and T. J. Podesta. "Pyridine boronic acids as building blocks in crystal engineering." Acta Crystallographica 61.Suppl (2001): C357.
Pyridine-4-boronic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou You Boron Photoelectric Material Co., Ltd. | 15301358979 | 37303017@qq.com | China | 494 | 58 |
| Zhuhai Aobokai Biomedical Technology Co., Ltd. | 400-0628126 | sales-team@aobchem.com.cn | China | 49999 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9409 | 55 |
| Energy Chemical | 400-0056266 18918157536; | sales8178@energy-chemical.com | China | 45000 | 61 |
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View Latest Price from Pyridine-4-boronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-23 | Pyridine-4-boronic acid
1692-15-5
|
$10.00 | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2023-11-27 | Pyridine-4-boronic acid
1692-15-5
|
1kg | 99.9% | 30000 Kg | Hebei Xinsheng New Material Technology Co., LTD. | ||
 |
2023-10-28 | 3-Pyridylboronic acid
1692-15-5
|
$25.00-35.00 | 1kg | 99% | 20 Ton | Hebei Xinsheng New Material Technology Co., LTD. |
-
- Pyridine-4-boronic acid
1692-15-5
- $10.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- Pyridine-4-boronic acid
1692-15-5
- 99.9%
- Hebei Xinsheng New Material Technology Co., LTD.
-
- 3-Pyridylboronic acid
1692-15-5
- $25.00-35.00
- 99%
- Hebei Xinsheng New Material Technology Co., LTD.
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