Pyridine-4-boronic acid
- CAS No.
- 1692-15-5
- Chemical Name:
- Pyridine-4-boronic acid
- Synonyms
- PYRIDIN-4-YLBORONIC ACID;4-PYRIDYLBORONIC ACID;4-PYRIDINYLBORONIC ACID;4-PYRIDINEBORONIC ACID;Pyridin-4-ylboronic acid, 97%, May contain varying aMounts of anhydride;AKOS BRN-0273;4-Boronopyridine;BUTTPARK 43\57-08;4-Pyridineboronic;TIMTEC-BB SBB004280
- CBNumber:
- CB7220144
- Molecular Formula:
- C5H6BNO2
- Molecular Weight:
- 122.92
- MDL Number:
- MFCD01074545
- MOL File:
- 1692-15-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-Pyridinylboronic acid 90% | 634492 | 1g | $44.4 |
| 4-Pyridinylboronic acid 90% | 634492 | 5g | $105.8 |
| 4-Pyridylboronic Acid (contains varying amounts of Anhydride) | P1594 | 1g | $20 |
| 4-Pyridylboronic Acid (contains varying amounts of Anhydride) | P1594 | 5g | $64 |
| 4-Pyridinylboronic acid 90% | 634492 | 25g | $137 |
| More product size | |||
| Melting point | >300 °C (lit.) |
|---|---|
| Boiling point | 308.8±34.0 °C(Predicted) |
| Density | 1.22±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Aqueous Acid (Slightly), Water (Slightly) |
| form | Solid |
| pka | 7.59±0.10(Predicted) |
| color | White to Off-White |
| BRN | 471944 |
| InChI | InChI=1S/C5H6BNO2/c8-6(9)5-1-3-7-4-2-5/h1-4,8-9H |
| InChIKey | QLULGIRFKAWHOJ-UHFFFAOYSA-N |
| SMILES | C1=NC=CC(B(O)O)=C1 |
| CAS DataBase Reference | 1692-15-5(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn,Xi,C,F | |||||||||
| Risk Statements | 36/37/38-22-34-11 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26-45-16 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | IRRITANT, KEEP COLD | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
Pyridine-4-boronic acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 634492 | 4-Pyridinylboronic acid 90% | 1692-15-5 | 1g | $44.4 | 2025-07-31 | Buy |
| Sigma-Aldrich | 634492 | 4-Pyridinylboronic acid 90% | 1692-15-5 | 5g | $105.8 | 2025-07-31 | Buy |
| TCI Chemical | P1594 | 4-Pyridylboronic Acid (contains varying amounts of Anhydride) | 1692-15-5 | 1g | $20 | 2025-07-31 | Buy |
| TCI Chemical | P1594 | 4-Pyridylboronic Acid (contains varying amounts of Anhydride) | 1692-15-5 | 5g | $64 | 2025-07-31 | Buy |
| Sigma-Aldrich | 634492 | 4-Pyridinylboronic acid 90% | 1692-15-5 | 25g | $137 | 2025-07-31 | Buy |
Pyridine-4-boronic acid Chemical Properties,Uses,Production
Uses
Pyridine-4-boronic acid can be used as a candidate for Suzuki-Miyaura coupling reaction. Especially, as a N-containing building blocks, pyridine-4-boronic acid was employed to construct some heterocyclic compounds with superior biological activities.
Description
Pyridine-4-boronic acid is a kind of boronic acid derivative. It is useful building blocks in crystal engineering. It can also be used as a catalyst to act as a dehydrative condensation agent to synthesize amides using carboxylic acid and amines as raw materials. Its derivative, polystyrene-bound 4-pyridineboronic acid, is a useful catalyst for amidation reaction and esterification of alpha-hydrocarboxylic acids.
Chemical Properties
light orange granular powder
Uses
Boronic acid derivatives and their binding affinities with diols.
Uses
Reagent used for
- Palladium-catalyzed Suzuki-Miyaura coupling reactions
- Ligand-free palladium-catalyzed Suzuki coupling reaction under microwave irradation
Reagent used in Preparation of
- HIV-1 protease inhibitors
- Potential cancer threapeutics, such as PDK1 and protein kinase CK2 inhibitors
Uses
suzuki reaction
Synthesis
1120-87-2
121-43-7
7732-18-5
1692-15-5
Under argon protection, 4-bromopyridine (1.5 g, 10 mmol) was placed in a 200 mL Schlenk flask and 40 mL of anhydrous deoxytetrahydrofuran was added. After cooling the reaction mixture to -78 °C, 5 mL (2.2 M, 11 mmol) of n-butyllithium solution was slowly added dropwise and the reaction was maintained at this temperature for 1 hour. Subsequently, 4 mL of trimethyl borate was added and the reaction continued at -78 °C for 1 hour. Upon completion of the reaction, the mixture was slowly warmed to room temperature and stirred overnight. The reaction was quenched with 2 mol/L hydrochloric acid solution and purified by recrystallization from hexane to give pyridine-4-boronic acid hydrochloride (0.8 g, 65% yield).
References
http://www.wako-chem.co.jp/english/labchem/product/Org/pyridineboronic/
José J. CamposGaxiola et al. "Pyridineboronic Acids as Useful Building Blocks in Combination with Perchloroplatinate(II) and -(IV) Salts: 1D, 2D, and 3D Hydrogen-Bonded Networks Containing X-H•••Cl2Pt− (X = C, N+), B(OH)2•••Cl2Pt−, and B(OH)2•••(HO)2B Synthons." Crystal Growth & Design 10.7(2010).
Kara, H., A. G. Orpen, and T. J. Podesta. "Pyridine boronic acids as building blocks in crystal engineering." Acta Crystallographica 61.Suppl (2001): C357.
Pyridine-4-boronic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1085 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Hebei Junhua Import and Export Co., LTD | +85259680964 | junhua1@hb-junhua.com | China | 933 | 58 |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | info@spring-chem.com | China | 2068 | 57 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13505 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21616 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 988 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
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View Lastest Price from Pyridine-4-boronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-07 | Pyridine-4-boronic acid
1692-15-5
|
US $0.00-0.00 / kg | 1kg | 99% | 1000kg | Hebei Junhua Import and Export Co., LTD | |
 |
2025-11-07 | Rivaroxaban
1692-15-5
|
US $0.00-0.00 / kg | 1kg | 99% | 1000kg | Hebei Junhua Import and Export Co., LTD | |
 |
2025-08-08 | Pyridine-4-boronic acid
1692-15-5
|
US $0.00 / Kg/Drum | 1Kg/Drum | 99% | 5000KG | Sichuan Zhuoyu Yantang Technology Co., Ltd. |
-
- Pyridine-4-boronic acid
1692-15-5
- US $0.00-0.00 / kg
- 99%
- Hebei Junhua Import and Export Co., LTD
-
- Rivaroxaban
1692-15-5
- US $0.00-0.00 / kg
- 99%
- Hebei Junhua Import and Export Co., LTD
-
- Pyridine-4-boronic acid
1692-15-5
- US $0.00 / Kg/Drum
- 99%
- Sichuan Zhuoyu Yantang Technology Co., Ltd.
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