4-(6-CHLORO-2-METHYLPYRIMIDIN-4-YL)MORPHOLINE synthesis
- Product Name:4-(6-CHLORO-2-METHYLPYRIMIDIN-4-YL)MORPHOLINE
- CAS Number:22177-99-7
- Molecular formula:C9H12ClN3O
- Molecular Weight:213.66
110-91-8
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1780-26-3
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22177-99-7
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$89.00/500mg
Yield:22177-99-7 72%
Reaction Conditions:
in water;
Steps:
4-(6-Chloro-2-methyl-pyrimidin-4-yl)-morpholine
4-(6-Chloro-2-methyl-pyrimidin-4-yl)-morpholine A mixture of morpholine (2.36 ml, 27.0 mmol) and 4,6-dichloro-2-methyl-pyrimidine (2.0 g, 12.3 mmol) in water (20 ml) was heated at 100° C. for 2 h. The reaction was allowed to cool to room temperature and was diluted with water (20 ml). The resulting precipitate was collected by filtration to give the title compound (1.90 g, 72% yield).
References:
US2012/202806,2012,A1