ChemicalBook CAS DataBase List 4,6-Dichloro-2-pyridinecarboxylic acid

4,6-Dichloro-2-pyridinecarboxylic acid synthesis

9synthesis methods

Product Name:4,6-Dichloro-2-pyridinecarboxylic acid
CAS Number:88912-25-8
Molecular formula:C6H3Cl2NO2
Molecular Weight:192

Methyl 4,6-dichloropyridine-2-carboxylate

98273-19-9

88912-25-8

Synthesis of 4,6-dichloropyridine-2-carboxylic acid [Compound (II-17)]: a mixture of ethyl 4,6-dichloropyridinecarboxylate (0.5 g, 2.43 mmol) with sodium hydroxide (0.11 g, 2.67 mmol) was stirred in 1.1 mL of water and 11 mL of ethanol and reacted for 1 hr at 60 °C. After completion of the reaction, ethanol was removed by distillation and the residue was washed with dichloromethane. The aqueous layer was acidified with dilute hydrochloric acid and extracted with ethyl acetate. The organic phase was washed with saturated brine solution and dried over anhydrous sodium sulfate. A white solid product was obtained, yield: 0.46 g, yield: 98.7%, melting point: 114-116 °C. IR (KBr, cm-1): 3562, 1692, 1557, 1395, 1287, 819.

98273-19-9 Synthesis

98273-19-9
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88912-25-8
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Yield:88912-25-8 98.7%

Reaction Conditions:

with sodium hydroxide in ethanol;water

Steps:

S.20.3 (3)
(3) Synthesis of 4,6-Dichloropicolinic Acid [Compound (II-17)] 4,6-Dichloropicolinic acid methyl ester (0.5 g, 2.43 mmol) was stirred in a mixture of sodium hydroxide (0.11 g, 2.43*1.1 mmol), 1.1 ml of water and 11 ml of ethanol at 60° C. for 1 hour. Ethanol in the reaction solution was distilled off and the residue was washed with dichloromethane. The aqueous layer was acidified with diluted hydrochloric acid. After being extracted with ethyl acetate, the product was washed with saturated saline solution and dried with sodium sulfate. White solid, yield: 0.46 g, percent yield: 98.7%, m.p.: 114-116° C. IR KBr cm^-1: 3562, 1692, 1557, 1395, 1287, 819.

References:

Kureha Kagaku Kogyo K.K. US6610853, 2003, B1

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