(4,7-Dimethoxy-1H-benzo[d]imidazol-2-yl)methanol synthesis
- Product Name:(4,7-Dimethoxy-1H-benzo[d]imidazol-2-yl)methanol
- CAS Number:103151-22-0
- Molecular formula:C10H12N2O3
- Molecular Weight:208.2139
Yield:103151-22-0 78%
Reaction Conditions:
Stage #1: 1,4-dimethoxybezenewith nitric acid at 90; for 1 h;Nitration;
Stage #2: with hydrogenchloride;tin(ll) chloride at 90 - 100; for 2 h;Reduction;
Stage #3: glycolic Acid in water;Heating;Further stages.;Cyclization;
References:
Flader;Liu;Borch [Journal of Medicinal Chemistry,2000,vol. 43,# 16,p. 3157 - 3167]
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