4-ALLYL-5-PHENYL-4H-[1,2,4]TRIAZOLE-3-THIOL synthesis
- Product Name:4-ALLYL-5-PHENYL-4H-[1,2,4]TRIAZOLE-3-THIOL
- CAS Number:23714-53-6
- Molecular formula:C11H11N3S
- Molecular Weight:217.29
![Benzoic acid, 2-[(2-propen-1-ylaMino)thioxoMethyl]hydrazide](/CAS/20150408/GIF/26029-04-9.gif)
26029-04-9
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23714-53-6
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Yield:23714-53-6 412 mg
Reaction Conditions:
with potassium hydroxide in ethanol;water at 100;
Steps:
4.1.1.2 4.1.1.2. Cyclization
General procedure: The thiosemicarbazide intermediates were solubilized in a mixture of water and ethanol (2:3) and KOH (3 equiv., 3mmol) was added. After refluxing for 2h, the mixture was neutralized with saturated aqueous KHSO4 and extracted twice with DCM. The organic phases were mixed, dried over MgSO4, filtered and evaporated under vacuum. The residues were purified by gel column chromatography (EtOAc/Hexane) or by reverse phase HPLC.
References:
Gavara, Laurent;Legru, Alice;Verdirosa, Federica;Sevaille, Laurent;Nauton, Lionel;Corsica, Giuseppina;Mercuri, Paola Sandra;Sannio, Filomena;Feller, Georges;Coulon, Rémi;De Luca, Filomena;Cerboni, Giulia;Tanfoni, Silvia;Chelini, Giulia;Galleni, Moreno;Docquier, Jean-Denis;Hernandez, Jean-Fran?ois [Bioorganic Chemistry,2021,vol. 113,art. no. 105024]
613-94-5
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23714-53-6
13 suppliers
$57.50/250mg
93-89-0
532 suppliers
$13.00/100g
23714-53-6
13 suppliers
$57.50/250mg
65-85-0
1401 suppliers
$10.00/25g
23714-53-6
13 suppliers
$57.50/250mg