4-amino-3,5-dimethyl-pyrazol synthesis
- Product Name:4-amino-3,5-dimethyl-pyrazol
- CAS Number:5272-86-6
- Molecular formula:C5H9N3
- Molecular Weight:111.15
14531-55-6
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5272-86-6
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Yield:5272-86-6 86%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in ethanol under 2250.23 Torr; for 6 h;Autoclave;
Steps:
5.1 Step 1: 3,5-dimethyl-1H-pyrazol-4-amine
3,5-dimethyl-4-nitro-1 H-pyrazole (3.0 g, 21.3 mmol, see international patent application WO 2003057673) was dissolvedin an autoclave in EtOH (50 mL) and added 10% Pd/C (1.0 g). Then 3 bar of H2 were applied to the reaction, which wasstirred for 6 h. The suspension was filtered over celite, washed with EtOH, and the filtrate was concentrated in vacuo.The product (2.0 g, 86%) was crystallized from an EtOH/EtOAc mixture
References:
Deutsches Krebsforschungszentrum;MILLER, Aubry;SCHÜLER, Peter;DE VITA, Elena EP3305781, 2018, A1 Location in patent:Paragraph 0235
29917-12-2
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5272-86-6
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1122-04-9
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5272-86-6
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123-54-6
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5272-86-6
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3656-05-1
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5272-86-6
68 suppliers
$45.00/100mg