4-Amino-6-methoxypyridazine synthesis
- Product Name:4-Amino-6-methoxypyridazine
- CAS Number:89179-64-6
- Molecular formula:C5H7N3O
- Molecular Weight:125.13
29049-45-4
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Yield:89179-64-6 51%
Reaction Conditions:
in methanol at 75;
Steps:
1.Q Synthetic Method Q: Synthesis of Example 136
A solution of R-21 (1.0 g, 7.75 mmol) in MeOH (20 ml) is added MeONa (1.255 g, 23.25 mmol), and then is stirred at 75 °C overnight. The mixture is concentrated under reduced pressure. The residue is purified by flash chromatography (S1O2 eluting with 65 % of EtOAc in petroleum ether) to give 1-7 (500 mg, 51%).
References:
WO2020/252229,2020,A2 Location in patent:Paragraph 0274; 0328-0329