4-aminobutyronitrile synthesis
- Product Name:4-aminobutyronitrile
- CAS Number:32754-99-7
- Molecular formula:C4H8N2
- Molecular Weight:84.12
58763-41-0
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Yield: 95.2%
Reaction Conditions:
with 5%-palladium/activated carbon;hydrogen in methanol;water at 20 - 25; under 1520.1 - 3040.2 Torr; for 4 h;Autoclave;Solvent;Reagent/catalyst;Temperature;
Steps:
3-4 Example 3: Preparation of 4-aminobutyronitrile (IV)
Into a 500 ml autoclave, add 220 g of methanol, 45.6 g (0.4 mol) of 4-nitrobutyronitrile obtained in Example 1, 0.6 g of 5% palladium-carbon catalyst (water 50%), and replace with nitrogen three times. Stir the reaction at a temperature of 20-25 °C, hydrogen pressure of 2-4 atmospheres for 4 hours, filter to recover the catalyst, wash the filter cake with 20 grams of methanol, and distill the filtrate to recover methanol. Then, distillation under reduced pressure (60-70 °C/5mmHg) gave 32.0 g of colorless liquid 4-aminobutyronitrile with a yield of 95.2% and a GC purity of 99.6%.
References:
Xin Fa Pharmaceutical Co., Ltd.;Fan Yansen;Qi Yuxin;Wang Baolin;Liu Yuesheng;Qu Hu;Zhou Lishan CN110878042, 2020, A Location in patent:Paragraph 0077-0080
21994-40-1
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3184-61-0
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5332-06-9
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$10.00/1g
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3184-13-2
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$5.00/250mg
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