4-Boc-1-piperazineacetic acid synthesis
- Product Name:4-Boc-1-piperazineacetic acid
- CAS Number:156478-71-6
- Molecular formula:C11H20N2O4
- Molecular Weight:244.29
209667-59-4
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156478-71-6
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Yield: 76%
Reaction Conditions:
with sodium hydroxide in methanol;water at 20; for 2 h;
Steps:
23.b b) 2-(4-(tert-Butoxycarbonyl) piperazin-l-yl) acetic acid
b) 2-(4-(tert-Butoxycarbonyl) piperazin-l-yl) acetic acidTo a solution of the compound of Intermediate Example 23(a) (1.5 g, 5.51 mmol) in methanol (10 ml) was added aqueous solution of NaOH (0.8 g, 22.0 mmol, 4 eq). The mixture was stirred at RT for 2 h. The mixture was concentrated and extracted as in Intermediate Example 5(c). The solvent was distilled off to give the product in 76 % yield (1 g). LC-MS (ESI): Calculated mass: 244.29; Observed mass: 145.1 [M- Boc+H] + (rt: 0.102 min).
References:
ORION CORPORATION;LINNANEN, Tero;WOHLFAHRT, Gerd;NANDURI, Srinivas;UJJINAMATADA, Ravi;RAJAGOPALAN, Srinivasan;MUKHERJEE, Subhendu WO2013/53983, 2013, A1 Location in patent:Page/Page column 42
7646-93-7
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209667-59-4
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$60.00/100mg
156478-71-6
113 suppliers
$6.00/100mg
57260-71-6
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156478-71-6
113 suppliers
$6.00/100mg