4-BROMO-2-FLUOROBENZAMIDE synthesis
- Product Name:4-BROMO-2-FLUOROBENZAMIDE
- CAS Number:292621-45-5
- Molecular formula:C7H5BrFNO
- Molecular Weight:218.02
105942-08-3
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292621-45-5
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$35.00/250mg
Yield:292621-45-5 98%
Reaction Conditions:
with aluminum oxide;methanesulfonate at 120; for 0.5 h;
Steps:
Charge a flask with acidic alumina (Al2O3) (3.03 g, 29.718 mmol) and methanesulfonic acid (10 mL). Heat the resulting solution to 12O0C, and add 4-bromo-2-fluorobenzonitrile (2.00 g, 9.999 mmol) in one portion. Stir the resulting mixture for 30 minutes, then cool the reaction to room temperature and pour it into water (50 mL). Extract the aqueous mixture with dichloromethane (3 x 30 mL). Combine the organic extracts; dry(Na2SO4); remove the solids by filtration; and concentrate the filtrate in vacuo, affording 2.14 g (98%) 4-bromo-2-fluoro-benzamide as a white solid. 1HNMR (DMSO-U5) δ 7.706 (d, 2H, J = 21.1 Hz), 7.598 (dd, IH, J= 1.9, 10.1 Hz), 7.557 (dd, IH, J= 8.0, 8.0 Hz), 7.446 (ddd, IH, J= 0.4, 1.9, 8.1 Hz).
References:
WO2007/87488,2007,A2 Location in patent:Page/Page column 24
112704-79-7
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$15.00/5G
292621-45-5
86 suppliers
$35.00/250mg
151982-51-3
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$9.00/250mg
292621-45-5
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7664-41-7
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$15.00/100ml
112704-79-7
538 suppliers
$15.00/5G
292621-45-5
86 suppliers
$35.00/250mg