4-bromo-3-formylbenzoic acid synthesis
- Product Name:4-bromo-3-formylbenzoic acid
- CAS Number:776315-23-2
- Molecular formula:C8H5BrO3
- Molecular Weight:229.03
858124-35-3
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776315-23-2
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Yield: 100%
Reaction Conditions:
with water;lithium hydroxide in tetrahydrofuran at 20; for 2 h;
Steps:
49.A Step C: 4-bromo-3-(2-carboxyethyl)benzoic acid
General procedure: Lithium hydroxide (111.7 mg; 4.66 mmol; 3.00 eq.) was added to a solution of methyl 4-bromo-3-(3-ethoxy-3-oxo-propyl)benzoate (490.0 mg; 1.55 mmol; 1.00 eq.) in THF (12 mL) and water (4 mL).
The reaction was then stirred 2h at rt then THF was evaporated and the residue was diluted with water.
The pH was adjusted to 1 with 1N HCl and the precipitate obtained was filtered, washed with water and dried under vacuum to give 4-bromo-3-(2-carboxyethyl)benzoic acid (374.7 mg; 71%) as a white solid.
References:
Inventiva;BARTH, Martine;CONTAL, Sylvie;JUNIEN, Jean-Louis;MASSARDIER, Christine;MONTALBETTI, Christian;SOUDE, Anne EP3632908, 2020, A1 Location in patent:Paragraph 0180; 0182; 0196
201230-82-2
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479258-37-2
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776315-23-2
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