ChemicalBook CAS DataBase List Methyl 4-bromo-3-methylbenzoate

Methyl 4-bromo-3-methylbenzoate synthesis

5synthesis methods

Product Name:Methyl 4-bromo-3-methylbenzoate
CAS Number:148547-19-7
Molecular formula:C9H9BrO2
Molecular Weight:229.07

67-56-1

7697-28-1

148547-19-7

To a concentrated solution of 4-bromo-3-methylbenzoic acid (3 g, 13.19 mmol) in methanol (15 ml) was added concentrated sulfuric acid (catalytic amount). The reaction mixture was heated to reflux for 14 hours and subsequently cooled to 0°C. The reaction mixture was neutralized with saturated sodium bicarbonate solution and the precipitated solid product was collected by filtration. The crude product was purified by silica gel column chromatography to afford methyl 4-bromo-3-methylbenzoate (3.1 g, 97% yield) as a white solid.

67-56-1 Synthesis

67-56-1
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148547-19-7
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Yield:148547-19-7 97%

Reaction Conditions:

with sulfuric acid in methanol for 14 h;Reflux;

Steps:

1.22
To a solution of 4-Bromo-3-methyl-benzoic acid (3 g, 13.19 mmol) in MeOH (15 ml) was added conc. H₂SO₄ (0.6 ml). The mixture was refluxed for 14 h, cooled to 0° C., nuetralized with saturated NaHCO₃, and filtered to give a solid. This material was purified by column chromatography to give 4-Bromo-3-methyl-benzoic acid methyl ester (3.1 g, 97%) as a white solid.

References:

Alam, Muzaffar;Du Bois, Daisy Joe;Hawley, Ronald Charles;Kennedy-Smith, Joshua;Minatti, Ana Elena;Palmer, Wylie Solang;Silva, Tania;Wilhelm, Robert Stephen US2011/71150, 2011, A1 Location in patent:Page/Page column 33

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7697-28-1
252 suppliers
$16.00/5 g

148547-19-7
195 suppliers
$6.00/1g

References

7697-28-1
252 suppliers
$16.00/5 g