4-BROMO-3-METHYLBENZHYDRAZIDE synthesis
- Product Name:4-BROMO-3-METHYLBENZHYDRAZIDE
- CAS Number:148672-43-9
- Molecular formula:C8H9BrN2O
- Molecular Weight:229.07
1447727-21-0
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Yield:148672-43-9 90.5%
Reaction Conditions:
with hydrogenchloride in ethyl acetate at 0 - 30; for 18 h;Inert atmosphere;
Steps:
17.2 Step 2: Preparation of 4-bromo-3-methylbenzohydrazide (17C)
Tert-butyl 2-(4-bromo-3-methylbenzoyl)hydrazine-1-carboxylate (8.90 g, 27.1 mmol) and ethyl acetate (50 mL) were added to a reaction flask, followed by the addition of a saturated solution (40 mL) of hydrochloric acid in ethyl acetate at 0°C. The reaction solution was stirred at room temperature for 18 hours. After completion of the reaction, the reaction solution was adjusted to pH=8~9 with saturated sodium bicarbonate solution, filtered and dried to obtain 5.60 g of the title product as a white solid, yield: 90.5%.
References:
EP3919489,2021,A1 Location in patent:Paragraph 0094; 0098; 0175; 0177
148547-19-7
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