4-Bromo-5-(4-fluorophenyl)-1(2)H-pyrazole synthesis
- Product Name:4-Bromo-5-(4-fluorophenyl)-1(2)H-pyrazole
- CAS Number:474706-36-0
- Molecular formula:C9H6BrFN2
- Molecular Weight:241.06
154258-82-9
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474706-36-0
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$60.00/100mg
Yield:474706-36-0 99%
Reaction Conditions:
with NBS in N,N-dimethyl-formamide at 20; for 1 h;
Steps:
Intermediate 2A: 4-Bromo-3 -(4-fluorophenyl)- lH-pyrazole
To a solution of 3-(4-fluorophenyl)-lH-pyrazole (10 g, 61.7 mmol) in DMF (50 ml) was added NBS (11 g, 61.7 mmol). The reaction mixture was stirred at rt for lh, quenched with water, extracted with EtOAc. The organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to give the crude product Intermediate 2A (14.47 g, 99%) as a white solid. MS(ES): m/z= 240.89/242.89 [M+H]+. HPLC Ret time (Method B): 3.56 min. NMR (400MHz, chloroform-d) δ 7.86 - 7.74 (m, 2H), 7.66 (s, 1H), 7.20 - 7.1 1 (m, 2H).
References:
WO2014/100540,2014,A1 Location in patent:Page/Page column 55
138716-20-8
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474706-36-0
30 suppliers
$60.00/100mg
403-42-9
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474706-36-0
30 suppliers
$60.00/100mg