4-BROMO-7-NITROISOQUINOLIN-1(2H)-ONE synthesis
- Product Name:4-BROMO-7-NITROISOQUINOLIN-1(2H)-ONE
- CAS Number:1036390-36-9
- Molecular formula:C9H5BrN2O3
- Molecular Weight:269.05
1975-52-6
283 suppliers
$12.00/1g
1036390-36-9
4 suppliers
inquiry
Yield:-
Steps:
Multi-step reaction with 5 steps
1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3.5 h / 80 °C / Inert atmosphere
2: dichloromethane / 0.5 h / 20 °C / Inert atmosphere
3: neat (no solvent) / 115 °C / Inert atmosphere
4: ammonia / ethylene glycol / 150 °C / Microwave irradiation
5: N-Bromosuccinimide / N,N-dimethyl acetamide / 0.17 h / 200 °C / Microwave irradiation
References:
Wurtz, Nicholas R.;Parkhurst, Brandon L.;Jiang, Wen;DeLucca, Indawati;Zhang, Xiaojun;Ladziata, Vladimir;Cheney, Daniel L.;Bozarth, Jeffrey R.;Rendina, Alan R.;Wei, Anzhi;Luettgen, Joseph M.;Wu, Yiming;Wong, Pancras C.;Seiffert, Dietmar A.;Wexler, Ruth R.;Priestley, E. Scott [ACS Medicinal Chemistry Letters,2016,vol. 7,# 12,p. 1077 - 1081]
77324-87-9
207 suppliers
$6.00/1g
1036390-36-9
4 suppliers
inquiry
64688-68-2
23 suppliers
inquiry
1036390-36-9
4 suppliers
inquiry
1036388-63-2
1 suppliers
inquiry
1036390-36-9
4 suppliers
inquiry
1036388-65-4
4 suppliers
inquiry
1036390-36-9
4 suppliers
inquiry